I have CLL, which has my spleen enlarged to 25 cm. Starting in Janurary 2018 I started injections of Rituxan. I had four of them and had terrible reactions on the 3rd and 4th injection. Now after a sonogram my spleen did not respond to the injections and only went down 1 cm. I don’t know what would be best to do now. Take regular Chemo injections or start the pill, Imbruvica. I would just like to talk to someone that has taken the bills. Thank you for your response.